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          CN 51-1193/Q
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Your Position :Home->Past Journals Catalog->2020 Vol.39 No.4

Effects of Two Chemical Drugs on the Behavior and Physiology of Eospalax baileyi
Author of the article:CAI Zhiyuan1,2, WANG Chan2, GUO Huailiang1,2, YAO Baohui1,2, TAN Yuchen1,2, SU Junhu1,2*
Author's Workplace:1. College of Grassland Science, Key Laboratory of Grassland Ecosystem(Ministry of Education), Pratacultural Engineering Laboratory of Gansu Province, Sino-U. S. Centers for Grazing Land Ecosystem Sustainability, Gansu Agricultural University, Lanzhou 730070, China;
2. Gansu Agricultural University-Massey University Research Centre for Grassland Biodiversity, Gansu Agricultural University, Lanzhou 730070, China
Key Words:anti-anxiety; stress; Eospalax baileyi; animal behavior; open field test; stress hormone
Abstract:To investigate the effects of 2 anti-anxiety chemicals (mifepristone and octreotide acetate) on the stress relief of plateau zokor (Eospalax baileyi). Intragastric saline was used as a control, and mifepristone at pre-selected concentration of 10 mg·mL-1 and octreotide acetate at concentration of 10 μg·mL-1 were used as treatment groups. After intragastric administration at 2 days interval in one week, the feed intake, body mass, heart rate, open field behavior, and hormone level of E. baileyi were measured. The results showed that in comparison to the control, the feed intake of the treatment groups were significantly increased (P<0.05); the central grid stay time of octreotide acetate group was significantly longer (P<0.05) in the open field behavior test, the frequency of modification in mifepristone group was significantly increased (P<0.05), and the climbing times and horizontal exercise of the treatment groups were significantly reduced (P<0.05); the levels of corticosterone and adrenocorticotropin hormones in the treatment groups were lower than those in the control group, and more significant in the mifepristone group (P<0.05). The comprehensive analysis showed that mifepristone could significantly alleviate the stress of E. baileyi in the indoor culture environment and played an essential role in improving its survival rate.
2020,39(4): 375-384 收稿日期:2020-01-08
分類號:Q959.837
基金項目:國家自然科學基金項目(31760706;31460566);甘肅省杰出青年基金項目(1606RJDA314);甘肅省隴原青年創新創業人才項目和甘肅農業大學青年導師基金項目(GAU-QDFC-2018-02)
作者簡介:蔡志遠,碩士研究生,草地保護專業,E-mail:[email protected]
*通信作者:蘇軍虎,E-mail:[email protected]
參考文獻:
安志芳, 魏琳娜, 王志潔, 等. 2020. 高原鼢鼠肝臟組織細胞周期相關基因的進化和表達[J]. 四川動物, 39(1):1-14.
程琪, 曲家鵬, 張賀, 等. 2017. 高原鼠兔個性特征的地理變異及其對環境的適應[J]. 獸類學報, 37(2):115-123.
陳光耀, 吳卓耘, 張新寧, 等. 2016. 柴胡加龍骨牡蠣湯對創傷后應激障礙模型大鼠行為學的調節作用[J]. 環球中醫藥, 9(2):138-141.
戴月琴. 2007. 甘肅鼢鼠(Myospalax cansus)的視器結構及辨色能力研究[D]. 西安:陜西師范大學.
樊乃昌, 施銀柱. 1982. 中國鼢鼠(EOSPALAX)亞屬分類研究[J]. 獸類學報, 2(2):183-199.
高博. 2015. 青陽參的抗應激效應:動物模型行為學研究[D]. 貴陽:貴州師范大學.
何誠. 2006. 實驗動物學[M]. 北京:中國農業大學出版社.
何嵐, 葛興芳, 劉剛, 等. 2014. 野生動物的應激狀態研究及其在物種保護上的應用[J]. 四川動物, 33(1):156-160.
賀爭鳴. 2010. 我國資源動物的實驗動物化潛力與展望[J]. 中國比較醫學雜志, 20(3):4-10.
姜春雷, 王云霞. 2015. 應激與疾病[M]. 上海:第二軍醫大學出版社.
姜龍. 2015. 三種中藥對雛雞免疫應激的緩解作用及作用機制研究[D]. 哈爾濱:東北農業大學.
康宇坤, 張德罡, 譚宇塵, 等. 2018. 高原鼢鼠微衛星多態位點篩選及其通用性檢測[J]. 草原與草坪, 38(2):56-60.
蘭玲. 2005. 焦慮大鼠內臟高敏感性與血清皮質酮的關系以及抗焦慮治療對二者的影響和意義[D]. 鄭州:鄭州大學.
李朝軍, 田澍遼, 王建堂, 等. 2015. 圈養條件下應激反應對野生動物的影響[J]. 獸醫導刊, 1(2):40.
李進軍. 2018. 動物免疫副反應處理方法及預防措施[J]. 中國畜禽種業, 14(7):40.
林曉春, 李云鵬, 卞艷芳, 等. 2010. 大鼠曠場實驗指標檢測及參考值的探討[J]. 毒理學雜志, 24(3):224-225.
劉文俊, 高宇婷, 竇智, 等. 2017. 探討曠場實驗評價脾氣虛和脾陽虛大鼠"神疲"的可能性及初步機制[J]. 中國當代醫藥, 24(21):4-10.
劉學森. 2017. 圈養珍稀野生動物應激性疾病及防治[J]. 農業與技術, 37(19):147-177.
史海霞, 董永麗, 楊儉勤, 等. 2019. 溫腎健脾法對腹瀉型腸易激綜合征大鼠內臟敏感性和曠場實驗的影響[J]. 世界中西醫結合雜志, 14(2):207-210.
宋川, 熊正英. 2013. 慢性不可預知性應激對大鼠體質量、攝食量和行為學的影響研究[J]. 遼寧體育科技, 35(1):11-13.
蘇軍虎, 紀維紅, 南志標, 等. 2015. 鼢鼠亞科Mysopalacinae動物系統學研究現狀與展望[J]. 動物學雜志, 50(4):649-658.
陶元清, 張靜宵. 1996. 青海省野生動物實驗動物化工作有關問題探討[J]. 地方病通報, 11(3):72-73.
王萬華, 王志永, 李勇軍, 等. 2009. 動物園動物的應激及其管理[J]. 野生動物, 30(6):30-32.
王曉君, 魏登邦, 魏蓮, 等. 2008. 高原鼢鼠和高原鼠兔肺細葉的結構特征[J]. 動物學報, 54(3):531-539.
王振龍, 劉季科. 2002. 艾鼬氣味對根田鼠社會行為和繁殖的影響[J]. 動物學報, 48(1):20-26.
吳紅芳, 金齊穎, 曹金英, 等. 2018. BDNF在慢性不可預見性溫和刺激應激大鼠海馬星形膠質細胞中的表達[J]. 安徽醫科大學學報, 53(9):61-64.
吳曉玲, 張貴鋒. 2018. 柴胡疏肝散對抑郁癥大鼠行為學及曠場實驗的影響[J]. 中國中醫藥現代遠程教育, 16(2):90-92.
徐佳. 2012. 豐富環境與應激對小鼠嗎啡行為敏感化的影響[D]. 北京:首都師范大學.
尤柯. 1990. 應激的概念及全身適應性綜合征的進展[J]. 西北國防醫學雜志, 11(3):80-81.
張強, 趙鵬鵬, 金學林, 等. 2011. 圈養珍稀野生動物應激性疾病及防治[J]. 動物醫學進展, 32(2):129-133.
張月萍, 王建軍. 2001. 攝食控制的神經體液機制研究進展[J]. 中國神經科學雜志, 17(4):350-353.
張強, 趙虎, 柳威, 等. 2009. 噻奈普汀與氟西汀對應激大鼠曠場行為及血清皮質酮水平影響的比較研究[J]. 中華行為醫學與腦科學雜志, 18(4):292-294.
張善超. 2010. 引起機體應激的因素及采取的措施[J]. 中國動物保健, 12(3):93-94.
張永賓, 伊霞, 王海鋒, 等. 2014. 中草藥添加劑在防治野生動物應激病中的應用研究[J]. 畜牧與飼料科學, 35(10):25-26.
張永賓, 伊霞, 王海鋒, 等. 2015. 應激對圈養野生動物的影響及防治措施[J]. 黑龍江畜牧獸醫, 3(5):229-231.
鄭玉瑤. 2016. 圈養珍稀野生動物應激性疾病及防治分析[J]. 甘肅畜牧獸醫, 46(9):41-42.
鐘文勤, 樊乃昌. 2002. 我國草地鼠害的發生原因及其生態治理對策[J]. 生物學通報, 37(7):1-4.
Alstott J, Timberlake W. 2009. Effects of rat sex differences and lighting on locomotor exploration of a circular open field with free-standing central corners and without peripheral walls[J]. Behavioural Brain Research, 196(2):214-219.
Choleris E, Thomas AW, Kavaliers M, et al. 2001. A detailed ethological analysis of the mouse open field test:effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field[J]. Neuroscience & Biobehavioral Reviews, 25(3):235-260.
Carrasco GA, Van de Kar LD. 2003. Neuroendocrine pharmacology of stress[J]. European Journal of Pharmacology, 463(1-3):235-272.
Dashow L, Epple A. 1985. Plasma catecholamines in the lamprey:intrinsic cardiovascular messengers[J]. Comparative Biochemistry and Physiology Part C:Comparative Pharmacology, 82(1):119-122.
Friard O, Gamba M. 2016. BORIS:a free, versatile open-source event-logging software for video/audio coding and live observations[J]. Methods in Ecology and Evolution, 7(11):1325-1330.
Gregory K, Panagiota P, Eva K, et al. 2011. Metabolic syndrome:definitions and controversies[J/OL]. BMC Medicine, 9(1):48[2019-10-30]. https://doi.org/10.1186/1741-7015-9-48.
Herman JP, Cullinan WE. 1997. Neurocircuitry of stress:central control of the hypothalamo-pituitary-adrenocortical axis[J]. Trends in Neurosciences, 20(2):78-84.
Karalis K, Muglia L, Bae D, et al. 1997. CRH and the immune system[J]. Journal of Neuroimmunology, 72(2):131-136.
Krantz SE. 1983. Cognitive appraisals and problem-directed coping:a prospective study of stress[J]. Journal of Personality and Social Psychology, 44(3):638-643.
Lazarus RS. 1985. The psychology of stress and coping[J]. Issues in Mental Health Nursing, 7(1-4):399-418.
Maier SF, Watkins LR. 1998. Cytokines for psychologists:implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition[J]. Psychological Review, 105(1):83-107.
Mason JW, Kosten TR, Southwick SM, et al. 1990. The use of psychoendocrine strategies in post-traumatic stress disorder 1[J]. Journal of Applied Social Psychology, 20(21):1822-1846.
Monclús R, Palomares F, Tablado Z, et al. 2009. Testing the threat-sensitive predator avoidance hypothesis:physiological responses and predator pressure in wild rabbits[J]. Oecologia, 158(4):615-623.
Qu JP, Fletcher QE, Réale Denis, et al. 2018. Independence between coping style and stress reactivity in plateau pika[J]. Physiology & Behavior, 197:1-8.
Scalera G, Tarozzi G. 2001. Sapid solutions and food intake in repeated dehydration and rehydration periods in rats[J]. Experimental Physiology, 86(4):489-498.
Selye H. 1976. Stress without distress[J]. Bruxelles Médical, 56(5):205-210.
Selye H. 1998. Asyndrome produced by diverse nocuous agents[J]. Journal of Neuropsychiatry, 10(2):230-231.
Suomi SJ. 1987. Genetic and maternal contributions to individual differences in rhesus monkey biobehavioral development[J]. Behavioral Biology, 10(21):397-419.
Tsigos C, Chrousos GP. 2002. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress[J]. Journal of Psychosomatic Research, 53(4):865-871.
Tan G, Dao TK, Farmer L, et al. 2011. Heart rate variability (HRV) and posttraumatic stress disorder (PTSD):a pilot study[J]. Applied Psychophysiology and Biofeedback, 36(1):27-35.
Wilson MA, Grillo CA, Fadel JR, et al. 2015. Stress as a one-armed bandit:differential effects of stress paradigms on the morphology, neurochemistry and behavior in the rodent amygdala[J]. Neurobiology of Stress, 1(6):195-208.
Walsh RN, Cummins RA. 1976. The open-field test:a critical review[J]. Psychological Bulletin, 83(3):482-504.
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